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MAPRE2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15555 |
| Other Accession | Q7ZXP1, Q3B8Q0, Q8R001, Q5ZKK1, Q3SZP2, NP_001137299.1, NP_055083.1, NP_001137298.1 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Mouse, Rat, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37031 Da |
| Antigen Region | 12-40 aa |
| Gene ID | 10982 |
|---|---|
| Other Names | Microtubule-associated protein RP/EB family member 2, APC-binding protein EB2, End-binding protein 2, EB2, MAPRE2, RP1 |
| Target/Specificity | This MAPRE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human MAPRE2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAPRE2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAPRE2 |
|---|---|
| Synonyms | RP1 |
| Function | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). |
| Cellular Location | Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules |
| Tissue Location | Expressed in different tumor cell lines. Up- regulated in activated B- and T-lymphocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
De Groot, C.O., et al. J. Biol. Chem. 285(8):5802-5814(2010)
Zhu, Z.C., et al. J. Biol. Chem. 284(47):32651-32661(2009)
Abiatari, I., et al. Int. J. Oncol. 35(5):1111-1116(2009)
Manna, T., et al. Biochemistry 47(2):779-786(2008)
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