LAT2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9GZY6 |
Other Accession | NP_054865.2, NP_115852.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 26550 Da |
Antigen Region | 107-135 aa |
Gene ID | 7462 |
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Other Names | Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5 |
Target/Specificity | This LAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the Central region of human LAT2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LAT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LAT2 |
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Synonyms | LAB, NTAL, WBS15, WBSCR15, WBSCR5 |
Function | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. |
Cellular Location | Cell membrane; Single-pass type III membrane protein Note=Present in lipid rafts |
Tissue Location | Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.
References
Rieke, C., et al. Cell. Signal. 22(3):395-403(2010)
Luo, X., et al. J. Clin. Endocrinol. Metab. 94(11):4533-4539(2009)
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Svojgr, K., et al. Immunol. Lett. 122(2):185-192(2009)
Whittaker, G.C., et al. Blood 112(7):2869-2877(2008)
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