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PNPLA3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NST1 |
| Other Accession | NP_079501.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52865 Da |
| Antigen Region | 109-137 aa |
| Gene ID | 80339 |
|---|---|
| Other Names | Patatin-like phospholipase domain-containing protein 3, Acylglycerol O-acyltransferase, 231-, Adiponutrin, Calcium-independent phospholipase A2-epsilon, iPLA2-epsilon, PNPLA3, ADPN, C22orf20 |
| Target/Specificity | This PNPLA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-137 amino acids from the N-terminal region of human PNPLA3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PNPLA3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLPL3 |
|---|---|
| Function | Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (PubMed:21878620). However, the triacylglycerol hydrolase activity is controversial and may be very low (PubMed:22560221). Possesses phospholipase A2 activity (PubMed:15364929). |
| Cellular Location | Membrane; Single-pass type II membrane protein. Lipid droplet |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.
References
Santoro, N., et al. Hepatology 52(4):1281-1290(2010)
Valenti, L., et al. Hepatology 52(4):1274-1280(2010)
Rotman, Y., et al. Hepatology 52(3):894-903(2010)
Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
Pare, G., et al. PLoS Genet. 6 (6), E1000981 (2010) :
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