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KBTBD10 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O60662 |
| Other Accession | Q9ER30, A2AUC9, NP_006054.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68037 Da |
| Antigen Region | 547-575 aa |
| Gene ID | 10324 |
|---|---|
| Other Names | Kelch-like protein 41, Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10, Kelch-related protein 1, Sarcosin, KLHL41, KBTBD10, KRP1 |
| Target/Specificity | This KBTBD10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 547-575 amino acids from the C-terminal region of human KBTBD10. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KBTBD10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLHL41 |
|---|---|
| Synonyms | KBTBD10, KRP1 |
| Function | Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A2AUC9}. Cell projection, pseudopodium {ECO:0000250|UniProtKB:Q9ER30}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9ER30}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:A2AUC9} Sarcoplasmic reticulum membrane Endoplasmic reticulum membrane Note=Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia. |
| Tissue Location | Sarcomeric muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
KBTBD10 is required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
References
Foster, L.J., et al. J. Proteome Res. 5(1):64-75(2006)
Lim, D.S., et al. J. Am. Coll. Cardiol. 38(4):1175-1180(2001)
Spence, H.J., et al. Oncogene 19(10):1266-1276(2000)
Taylor, A., et al. Mol. Cell. Biochem. 183 (1-2), 105-112 (1998) :
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