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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > GPR174 Antibody (C-term)
GPR174 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BXC1 |
| Other Accession | NP_115942.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38503 Da |
| Antigen Region | 283-310 aa |
| Gene ID | 84636 |
|---|---|
| Other Names | Probable G-protein coupled receptor 174, GPR174 |
| Target/Specificity | This GPR174 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-310 amino acids from the C-terminal region of human GPR174. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR174 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR174 |
|---|---|
| Function | G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:36823105). Plays a negative role in regulatory T-cell accumulation and homeostasis. Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response. Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells. Mechanistically, acts via G(12)/G(13)- containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling. Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions. Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells. Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Putative receptor for purines coupled to G-proteins (By similarity).
References
Takeda, S., et al. FEBS Lett. 520 (1-3), 97-101 (2002) :
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$ 192.50
$ 75.00
Cat# AP16459b
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