MNX1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P50219 |
Other Accession | Q9QZW9, NP_005506.3 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 40569 Da |
Antigen Region | 242-271 aa |
Gene ID | 3110 |
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Other Names | Motor neuron and pancreas homeobox protein 1, Homeobox protein HB9, MNX1, HLXB9 |
Target/Specificity | This MNX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-271 amino acids from the Central region of human MNX1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MNX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MNX1 |
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Synonyms | HLXB9 |
Function | Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Expressed in lymphoid and pancreatic tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
References
Turgut, M. Acta Neurochir (Wien) 152(6):1083-1084(2010)
Garcia-Barcelo, M.M., et al. J. Pediatr. Surg. 44(10):1892-1898(2009)
Park, J., et al. Cancer Genet. Cytogenet. 191(2):102-105(2009)
Ballabio, E., et al. Leukemia 23(6):1179-1182(2009)
Taketani, T., et al. Cancer Genet. Cytogenet. 186(2):115-119(2008)
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