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ISG20 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96AZ6 |
| Other Accession | NP_002192.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20363 Da |
| Antigen Region | 29-58 aa |
| Gene ID | 3669 |
|---|---|
| Other Names | Interferon-stimulated gene 20 kDa protein, Estrogen-regulated transcript 45 protein, Promyelocytic leukemia nuclear body-associated protein ISG20, ISG20, HEM45 |
| Target/Specificity | This ISG20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the Central region of human ISG20. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ISG20 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ISG20 |
|---|---|
| Synonyms | HEM45 |
| Function | Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA (PubMed:11401564, PubMed:12594219, PubMed:16033969). Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) (PubMed:16514659, PubMed:21036379). Inhibition of several viruses such as chikungunya virus (CHIKV) does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins (By similarity). Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies (PubMed:31600344). May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition (By similarity). May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (PubMed:16514659). |
| Cellular Location | Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body. Cytoplasm, P-body |
| Tissue Location | Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.
References
Hao, Y., et al. J. Huazhong Univ. Sci. Technol. Med. Sci. 28(1):11-13(2008)
Horio, T., et al. FEBS Lett. 577 (1-2), 111-116 (2004) :
Espert, L., et al. J. Biol. Chem. 278(18):16151-16158(2003)
Izmailova, E., et al. Nat. Med. 9(2):191-197(2003)
Nguyen, L.H., et al. Biochemistry 40(24):7174-7179(2001)
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