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SIRPG Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9P1W8 |
| Other Accession | NP_543006.2, NP_001034597.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42498 Da |
| Antigen Region | 193-221 aa |
| Gene ID | 55423 |
|---|---|
| Other Names | Signal-regulatory protein gamma, SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-b2, SIRP-beta-2, CD172g, SIRPG, SIRPB2 |
| Target/Specificity | This SIRPG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-221 amino acids from the Central region of human SIRPG. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SIRPG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIRPG |
|---|---|
| Synonyms | SIRPB2 |
| Function | Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen- specific T-cell proliferation and costimulates T-cell activation. |
| Cellular Location | Membrane; Single- pass type I membrane protein |
| Tissue Location | Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.
References
Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)
Kawasaki, M., et al. Clin. Exp. Rheumatol. 27(2):260-266(2009)
Stefanidakis, M., et al. Blood 112(4):1280-1289(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Barclay, A.N., et al. Nat. Rev. Immunol. 6(6):457-464(2006)
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