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NHLH2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q02577 |
| Other Accession | Q64221, NP_001104531.1, NP_005590.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15018 Da |
| Antigen Region | 63-91 aa |
| Gene ID | 4808 |
|---|---|
| Other Names | Helix-loop-helix protein 2, HEN-2, Class A basic helix-loop-helix protein 34, bHLHa34, Nescient helix loop helix 2, NSCL-2, NHLH2, BHLHA34, HEN2, KIAA0490 |
| Target/Specificity | This NHLH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the Central region of human NHLH2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NHLH2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NHLH2 |
|---|---|
| Synonyms | BHLHA34, HEN2, KIAA0490 |
| Function | Transcription factor which binds the E box motif 5'- CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including NDN, PCSK1, MC4R (By similarity). Is also a transcriptional activator of KISS1 (PubMed:35066646). May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with NHLH1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NHLH2 may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
References
Raychaudhuri, S., et al. Nat. Genet. 41(12):1313-1318(2009)
Good, D.J., et al. Exerc Sport Sci Rev 36(4):187-192(2008)
Aoyama, M., et al. Cancer Res. 65(11):4587-4597(2005)
Lipkowitz, S., et al. J. Biol. Chem. 267(29):21065-21071(1992)
Brown, L., et al. Proc. Natl. Acad. Sci. U.S.A. 89(18):8492-8496(1992)
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