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PRDM8 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NQV8 |
| Other Accession | Q8BZ97, NP_001092873.1, NP_064611.3 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 71663 Da |
| Antigen Region | 75-102 aa |
| Gene ID | 56978 |
|---|---|
| Other Names | PR domain zinc finger protein 8, 211-, PR domain-containing protein 8, PRDM8, PFM5 |
| Target/Specificity | This PRDM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-102 amino acids from the N-terminal region of human PRDM8. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRDM8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRDM8 |
|---|---|
| Synonyms | PFM5 |
| Function | Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in brain, heart, skeletal muscle, testes, prostate. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
PRDM8 may be involved in transcriptional regulation.
References
Newton-Cheh, C., et al. Nat. Genet. (2009) In press :
Xiao, B., et al. Curr. Opin. Struct. Biol. 13(6):699-705(2003)
Jiang, G.L., et al. Histol. Histopathol. 15(1):109-117(2000)
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