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KRT3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P12035 |
| Other Accession | NP_476429.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64417 Da |
| Antigen Region | 414-441 aa |
| Gene ID | 3850 |
|---|---|
| Other Names | Keratin, type II cytoskeletal 3, 65 kDa cytokeratin, Cytokeratin-3, CK-3, Keratin-3, K3, Type-II keratin Kb3, KRT3 |
| Target/Specificity | This KRT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-441 amino acids from the Central region of human KRT3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KRT3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRT3 |
|---|---|
| Tissue Location | Cornea specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
References
Szaflik, J.P., et al. Mol. Vis. 14, 1713-1718 (2008) :
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
Chen, Y.T., et al. Cornea 24(8):928-932(2005)
Rogers, M.A., et al. J. Invest. Dermatol. 124(3):536-544(2005)
Irvine, A.D., et al. Nat. Genet. 16(2):184-187(1997)
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