ZDHHC8 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9ULC8 |
Other Accession | Q5Y5T5, NP_037505.1, NP_001171953.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 81443 Da |
Antigen Region | 532-561 aa |
Gene ID | 29801 |
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Other Names | Probable palmitoyltransferase ZDHHC8, Zinc finger DHHC domain-containing protein 8, DHHC-8, Zinc finger protein 378, ZDHHC8, KIAA1292, ZDHHCL1, ZNF378 |
Target/Specificity | This ZDHHC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 532-561 amino acids from the C-terminal region of human ZDHHC8. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZDHHC8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZDHHC8 (HGNC:18474) |
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Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). |
Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:Q5Y5T5}; Multi-pass membrane protein |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.
References
Shin, H.D., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1167-1172 (2010) :
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Xu, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2010) In press :
Yang, W., et al. Mol. Cell Proteomics 9(1):54-70(2010)
Singaraja, R.R., et al. Circ. Res. 105(2):138-147(2009)
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