CGNL1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q0VF96 |
Other Accession | Q6AW69, NP_116255.2 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 149079 Da |
Antigen Region | 317-344 aa |
Gene ID | 84952 |
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Other Names | Cingulin-like protein 1, Junction-associated coiled-coil protein, Paracingulin, CGNL1, JACOP, KIAA1749 |
Target/Specificity | This CGNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-344 amino acids from the N-terminal region of human CGNL1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CGNL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CGNL1 |
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Synonyms | JACOP, KIAA1749 |
Function | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. |
Cellular Location | Cell junction, tight junction {ECO:0000250|UniProtKB:Q6AW69}. Note=Localizes to the apical junction complex composed of tight and adherens junctions (PubMed:22891260). In the liver and kidney, it is also found along non-junctional actin filament bundles in addition to the apical junction (By similarity) {ECO:0000250|UniProtKB:Q6AW69, ECO:0000269|PubMed:22891260} |
Tissue Location | Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of adult brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CGNL1 may be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons (By similarity).
References
Guillemot, L., et al. Mol. Biol. Cell 19(10):4442-4453(2008) Ohnishi, H., et al. J. Biol. Chem. 279(44):46014-46022(2004) Shozu, M., et al. N. Engl. J. Med. 348(19):1855-1865(2003)
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