GPR171 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O14626 |
Other Accession | NP_037440.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 36754 Da |
Antigen Region | 286-314 aa |
Gene ID | 29909 |
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Other Names | Probable G-protein coupled receptor 171, G-protein coupled receptor H963, GPR171, H963 |
Target/Specificity | This GPR171 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-314 amino acids from the C-terminal region of human GPR171. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GPR171 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GPR171 (HGNC:30057) |
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Synonyms | H963 |
Function | G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BG55}; Multi-pass membrane protein. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55} |
Tissue Location | Expressed in both T-cell subsets and natural killer cells, while it is undetectable in B cells or CD14(+) monocytes Expressed in peripheral blood mononuclear cells (PBMC) and Jurkat cells (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
GPR171 is orphan receptor.
References
Joensuu, T., et al. Am. J. Hum. Genet. 69(4):673-684(2001)
Jacobs, K.A., et al. Gene 198 (1-2), 289-296 (1997) :
Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :
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