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GPR171 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14626 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37 KDa |
| Gene ID | 29909 |
|---|---|
| Other Names | Probable G-protein coupled receptor 171, G-protein coupled receptor H963, GPR171, H963 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | GPR171 (HGNC:30057) |
|---|---|
| Synonyms | H963 |
| Function | G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BG55}; Multi-pass membrane protein. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55} |
| Tissue Location | Expressed in both T-cell subsets and natural killer cells, while it is undetectable in B cells or CD14(+) monocytes Expressed in peripheral blood mononuclear cells (PBMC) and Jurkat cells (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor.
References
Jacobs K.A.,et al.Gene 198:289-296(1997).
Joensuu T.,et al.Am. J. Hum. Genet. 69:673-684(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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