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SEC23A Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15436 |
| Other Accession | NP_006355.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86161 Da |
| Antigen Region | 299-328 aa |
| Gene ID | 10484 |
|---|---|
| Other Names | Protein transport protein Sec23A, SEC23-related protein A, SEC23A |
| Target/Specificity | This SEC23A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-328 amino acids from the Central region of human SEC23A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEC23A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEC23A (HGNC:10701) |
|---|---|
| Function | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity). |
| Cellular Location | Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Note=Enriched at endoplasmic reticulum exit sites, also known as transitional endoplasmic reticulum (tER) |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Townley, A.K., et al. J. Cell. Sci. 121 (PT 18), 3025-3034 (2008) :
Stagg, S.M., et al. Cell 134(3):474-484(2008)
Bi, X., et al. Dev. Cell 13(5):635-645(2007)
Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)
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