FAAH Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O00519 |
Other Accession | NP_001432.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 63066 Da |
Antigen Region | 501-529 aa |
Gene ID | 2166 |
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Other Names | Fatty-acid amide hydrolase 1, Anandamide amidohydrolase 1, Oleamide hydrolase 1, FAAH, FAAH1 |
Target/Specificity | This FAAH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-529 amino acids from the C-terminal region of human FAAH. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FAAH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FAAH |
---|---|
Synonyms | FAAH1 |
Function | Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-glycerol) (PubMed:21049984). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity). |
Cellular Location | Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network |
Tissue Location | Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
de Luis, D.A., et al. Metab. Clin. Exp. (2010) In press :
Monteleone, P., et al. J Clin Psychopharmacol 30(4):441-445(2010)
Taylor, A.H., et al. Histochem. Cell Biol. 133(5):557-565(2010)
Thors, L., et al. PLoS ONE 5 (8), E12275 (2010) :
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