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FAAH Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FAAH Antibody (C-term) AP17046B
    FAAH Antibody (C-term) (Cat. #AP17046b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the FAAH antibody detected the FAAH protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O00519
Other Accession NP_001432.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 63066 Da
Antigen Region 501-529 aa
Additional Information
Gene ID 2166
Other Names Fatty-acid amide hydrolase 1, Anandamide amidohydrolase 1, Oleamide hydrolase 1, FAAH, FAAH1
Target/Specificity This FAAH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-529 amino acids from the C-terminal region of human FAAH.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFAAH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FAAH
Synonyms FAAH1
Function Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-glycerol) (PubMed:21049984). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).
Cellular Location Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network
Tissue Location Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.
Research Areas
Citations (0)
citation

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Background

This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
de Luis, D.A., et al. Metab. Clin. Exp. (2010) In press :
Monteleone, P., et al. J Clin Psychopharmacol 30(4):441-445(2010)
Taylor, A.H., et al. Histochem. Cell Biol. 133(5):557-565(2010)
Thors, L., et al. PLoS ONE 5 (8), E12275 (2010) :

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$ 182.50
$ 70.00
Cat# AP17046B
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