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CRLF1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75462 |
| Other Accession | Q9JM58, NP_004741.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46302 Da |
| Antigen Region | 255-283 aa |
| Gene ID | 9244 |
|---|---|
| Other Names | Cytokine receptor-like factor 1, Cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1 |
| Target/Specificity | This CRLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-283 amino acids from the Central region of human CRLF1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CRLF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRLF1 |
|---|---|
| Function | In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system. |
| Cellular Location | Secreted. |
| Tissue Location | Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq].
References
Tsuritani, K., et al. Calcif. Tissue Int. 86(1):47-57(2010)
Crisponi, L., et al. Am. J. Hum. Genet. 80(5):971-981(2007)
Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Heese, K., et al. J. Cell. Biochem. 91(5):1030-1042(2004)
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