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MPI Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P34949 |
| Other Accession | Q924M7, Q3SZI0, NP_002426.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46656 Da |
| Antigen Region | 37-65 aa |
| Gene ID | 4351 |
|---|---|
| Other Names | Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI, MPI, PMI1 |
| Target/Specificity | This MPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human MPI. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MPI Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MPI (HGNC:7216) |
|---|---|
| Synonyms | PMI1 |
| Function | Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q924M7}. |
| Tissue Location | Expressed in all tissues, but more abundant in heart, brain and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
References
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Xiao, J., et al. J. Mol. Graph. Model. 25(3):289-295(2006)
Vuillaumier-Barrot, S., et al. J. Med. Genet. 39(11):849-851(2002)
Schollen, E., et al. Eur. J. Hum. Genet. 10(10):643-648(2002)
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