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PANX1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96RD7 |
| Other Accession | P60570, Q9JIP4, NP_056183.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48050 Da |
| Antigen Region | 124-152 aa |
| Gene ID | 24145 |
|---|---|
| Other Names | Pannexin-1, PANX1, MRS1 |
| Target/Specificity | This PANX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the Central region of human PANX1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PANX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PANX1 (HGNC:8599) |
|---|---|
| Function | Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:15304325, PubMed:16908669, PubMed:20829356, PubMed:20944749, PubMed:30918116). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)- leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351} |
| Tissue Location | Widely expressed (PubMed:30918116). Highest expression is observed in oocytes and brain (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq].
References
Chekeni, F.B., et al. Nature 467(7317):863-867(2010)
Sridharan, M., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (4), H1146-H1152 (2010) :
Ambrosi, C., et al. J. Biol. Chem. 285(32):24420-24431(2010)
Bhalla-Gehi, R., et al. J. Biol. Chem. 285(12):9147-9160(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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