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P2RX6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15547 |
| Other Accession | NP_001153026.1, NP_005437.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48829 Da |
| Antigen Region | 198-226 aa |
| Gene ID | 9127 |
|---|---|
| Other Names | P2X purinoceptor 6, P2X6, ATP receptor, P2XM, Purinergic receptor, Purinergic receptor P2X-like 1, P2RX6, P2RXL1, P2X6 |
| Target/Specificity | This P2RX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the Central region of human P2RX6. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P2RX6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | P2RX6 |
|---|---|
| Synonyms | P2RXL1, P2X6 |
| Function | Receptor for ATP that acts as a ligand-gated ion channel. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed predominantly in skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified.
References
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Luke, M.M., et al. Stroke 40(2):363-368(2009)
Palomino-Doza, J., et al. Hypertension 52(5):980-985(2008)
Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)
Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007)
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