Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
P2RX6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15547 |
| Other Accession | NP_001153026.1, NP_005437.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48829 Da |
| Antigen Region | 198-226 aa |
| Gene ID | 9127 |
|---|---|
| Other Names | P2X purinoceptor 6, P2X6, ATP receptor, P2XM, Purinergic receptor, Purinergic receptor P2X-like 1, P2RX6, P2RXL1, P2X6 |
| Target/Specificity | This P2RX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the Central region of human P2RX6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P2RX6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | P2RX6 |
|---|---|
| Synonyms | P2RXL1, P2X6 |
| Function | May act as a modulatory subunit rather than a functional channel. Unlike other P2XRs members, P2RX6 does not seem to form functional homotrimers (PubMed:22378790). P2RX6 requires the presence of P2RX4 or P2RX2 to shuttle it to the plasma membrane where it may form functional heterotrimeric receptors at the plasma membrane (PubMed:22378790). P2RX6 can be translocated to the nucleus and functions as a nuclear regulator of post-transcriptional modifications in neurons (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P51579}; Multi-pass membrane protein. Endoplasmic reticulum {ECO:0000250|UniProtKB:P51579}. Nucleus {ECO:0000250|UniProtKB:O54803} Nucleus inner membrane {ECO:0000250|UniProtKB:O54803}; Multi-pass membrane protein. Note=Heteromerization of P2RX6 subunits with either P2RX2 or P2RX4 subunits guides the P2RX6 subunit to the plasma membrane (By similarity). Monomers remain anchored to the endoplasmic reticulum (ER) membrane by the hydrophobic N-terminal end (By similarity). Mainly expressed in the cell body of the hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:O54803, ECO:0000250|UniProtKB:P51579} |
| Tissue Location | Expressed predominantly in skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified.
References
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Luke, M.M., et al. Stroke 40(2):363-368(2009)
Palomino-Doza, J., et al. Hypertension 52(5):980-985(2008)
Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)
Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
