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DNAJA2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O60884 |
| Other Accession | O35824, Q9QYJ0, Q2HJ94, NP_005871.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45746 Da |
| Antigen Region | 44-72 aa |
| Gene ID | 10294 |
|---|---|
| Other Names | DnaJ homolog subfamily A member 2, Cell cycle progression restoration gene 3 protein, Dnj3, Dj3, HIRA-interacting protein 4, Renal carcinoma antigen NY-REN-14, DNAJA2, CPR3, HIRIP4 |
| Target/Specificity | This DNAJA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human DNAJA2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DNAJA2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNAJA2 |
|---|---|
| Synonyms | CPR3, HIRIP4 |
| Function | Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). |
| Cellular Location | Membrane; Lipid-anchor |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro.
References
Walker, V.E., et al. J. Biol. Chem. 285(5):3319-3329(2010)
Rosales-Hernandez, A., et al. Cell Stress Chaperones 14(1):71-82(2009)
Tzankov, S., et al. J. Biol. Chem. 283(40):27100-27109(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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