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CNDP2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96KP4 |
| Other Accession | NP_060705.2, NP_001161971.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52878 Da |
| Antigen Region | 348-375 aa |
| Gene ID | 55748 |
|---|---|
| Other Names | Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2, CN2, CPGL, PEPA |
| Target/Specificity | This CNDP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-375 amino acids from the C-terminal region of human CNDP2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNDP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNDP2 {ECO:0000303|PubMed:25964343, ECO:0000312|HGNC:HGNC:24437} |
|---|---|
| Function | Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue- specific way (By similarity). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (PubMed:12473676, PubMed:19346245). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (PubMed:25964343). Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568). |
| Cellular Location | Cytoplasm |
| Tissue Location | [Isoform 1]: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level) (PubMed:24395568). |
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Provided below are standard protocols that you may find useful for product applications.
Background
CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).
References
Ahmed, A.H., et al. Biochemistry 49(13):2843-2850(2010)
McDonough, C.W., et al. Hum. Genet. 126(2):265-275(2009)
Wanic, K., et al. Diabetes 57(9):2547-2551(2008)
Wanic, K., et al. Diabetes (2008) In press :
Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)
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