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UBE2G1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P62253 |
| Other Accession | P62255, P62254, Q4R5Y8, NP_003333.1 |
| Reactivity | Human |
| Predicted | Monkey, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19509 Da |
| Antigen Region | 127-155 aa |
| Gene ID | 7326 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 G1, E217K, UBC7, Ubiquitin carrier protein G1, Ubiquitin-protein ligase G1, Ubiquitin-conjugating enzyme E2 G1, N-terminally processed, UBE2G1, UBE2G |
| Target/Specificity | This UBE2G1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the C-terminal region of human UBE2G1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UBE2G1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBE2G1 |
|---|---|
| Synonyms | UBE2G |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. |
| Tissue Location | Widely expressed, mainly in skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq].
References
Hassink, G., et al. Biochem. J. 388 (PT 2), 647-655 (2005) :
Kim, B.W., et al. Mol. Endocrinol. 17(12):2603-2612(2003)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Imai, Y., et al. Cell 105(7):891-902(2001)
Tiwari, S., et al. J. Biol. Chem. 276(19):16193-16200(2001)
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