BCL7B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9BQE9 |
Other Accession | Q921K9, Q3T0A6, NP_001698.2 |
Reactivity | Human, Mouse |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 22195 Da |
Antigen Region | 137-164 aa |
Gene ID | 9275 |
---|---|
Other Names | B-cell CLL/lymphoma 7 protein family member B, Hom s 3, BCL7B |
Target/Specificity | This BCL7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-164 amino acids from the C-terminal region of human BCL7B. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BCL7B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BCL7B |
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Function | Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene.
References
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)
Kathiresan, S., et al. Nat. Genet. 40(2):189-197(2008)
Willer, C.J., et al. Nat. Genet. 40(2):161-169(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jadayel, D.M., et al. Gene 224 (1-2), 35-44 (1998) :
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