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PDE4A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P27815 |
| Other Accession | NP_001104778.1, NP_001104777.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 98143 Da |
| Antigen Region | 32-61 aa |
| Gene ID | 5141 |
|---|---|
| Other Names | cAMP-specific 3', 5'-cyclic phosphodiesterase 4A, DPDE2, PDE46, PDE4A, DPDE2 |
| Target/Specificity | This PDE4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human PDE4A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDE4A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDE4A |
|---|---|
| Synonyms | DPDE2 |
| Function | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. |
| Cellular Location | [Isoform 1]: Cytoplasm, perinuclear region [Isoform 3]: Cytoplasm, cytosol [Isoform 6]: Cytoplasm, perinuclear region |
| Tissue Location | [Isoform 1]: Expressed in lymphoid cell subsets including CD8-positive T cells and T-helper 2 cells. Expressed in dendritic cells. [Isoform 6]: Expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Selige, J., et al. J. Cell. Physiol. 223(2):317-326(2010)
Bjorgo, E., et al. Mol. Cell. Biol. 30(7):1660-1672(2010)
Singh, D., et al. Respir. Res. 11, 26 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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