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ESX1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N693 |
| Other Accession | NP_703149.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44297 Da |
| Antigen Region | 28-55 aa |
| Gene ID | 80712 |
|---|---|
| Other Names | Homeobox protein ESX1, Extraembryonic, spermatogenesis, homeobox 1, Homeobox protein ESX1-N, Homeobox protein ESX1-C, ESX1, ESX1L, ESX1R |
| Target/Specificity | This ESX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-55 amino acids from the N-terminal region of human ESX1. |
| Dilution | WB~~1:1000-1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ESX1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ESX1 |
|---|---|
| Synonyms | ESX1L, ESX1R |
| Function | May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584} Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm |
| Tissue Location | Expressed in placenta and testis. Expressed in testicular germ cell tumors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.
References
Bonaparte, E., et al. Hum. Reprod. 25(6):1398-1403(2010)
Wang, X., et al. Hum. Mol. Genet. 16(17):2053-2060(2007)
Loschiavo, M., et al. Mamm. Genome 18(1):75-85(2007)
Murthi, P., et al. Mol. Hum. Reprod. 12(5):335-340(2006)
Yanagihara, M., et al. Oncogene 24(38):5878-5887(2005)
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