Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
IFRD2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q12894 |
| Other Accession | NP_006755.4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48048 Da |
| Antigen Region | 478-506 aa |
| Gene ID | 7866 |
|---|---|
| Other Names | Interferon-related developmental regulator 2, Protein SKMC15, IFRD2 |
| Target/Specificity | This IFRD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 478-506 amino acids from the C-terminal region of human IFRD2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IFRD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IFRD2 {ECO:0000303|PubMed:30355441, ECO:0000312|HGNC:HGNC:5457} |
|---|---|
| Function | Ribosome-binding protein that acts as an inhibitor of mRNA translation by promoting ribosome inactivation (PubMed:30355441). Associates with the P- and E-sites of the ribosome and inserts a C- terminal helix into the mRNA exit channel to preclude translation (By similarity). |
| Tissue Location | Expressed in many tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
IFRD2 contains a predicted bipartite nuclear localization signal and an armadillo-beta catenin-like repeat. It is highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis.
References
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
Lerman, M.I., et al. Cancer Res. 60(21):6116-6133(2000)
Buanne, P., et al. Genomics 51(2):233-242(1998)
Latif, F., et al. Hum. Genet. 99(3):334-341(1997)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
