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LAS1L Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y4W2 |
| Other Accession | NP_001164120.1, NP_001164121.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 83065 Da |
| Antigen Region | 639-665 aa |
| Gene ID | 81887 |
|---|---|
| Other Names | Ribosomal biogenesis protein LAS1L, Protein LAS1 homolog, LAS1L |
| Target/Specificity | This LAS1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639-665 amino acids from the C-terminal region of human LAS1L. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LAS1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LAS1L |
|---|---|
| Function | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). |
| Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:A2BE28}. Cytoplasm {ECO:0000250|UniProtKB:A2BE28}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. {ECO:0000250|UniProtKB:A2BE28} |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The function of LAS1L has not been determined.
References
Castle, C.D., et al. Mol. Cell. Biol. 30(18):4404-4414(2010)
Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
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$ 192.50
$ 75.00
Cat# AP17345B
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