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EVI2B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P34910 |
| Other Accession | NP_006486.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48666 Da |
| Antigen Region | 283-313 aa |
| Gene ID | 2124 |
|---|---|
| Other Names | Protein EVI2B, Ecotropic viral integration site 2B protein homolog, EVI-2B, CD361, EVI2B, EVDB |
| Target/Specificity | This EVI2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-313 amino acids from the Central region of human EVI2B. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EVI2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EVI2B {ECO:0000303|PubMed:1903357, ECO:0000312|HGNC:HGNC:3500} |
|---|---|
| Function | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines. Strongly expressed in granulocytic cells, and weakly on lymphocytes cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
EVI2B (Ecotropic viral integration site 2B) may function as an oncogene in retrovirus-induced myeloid tumors and may have a role in leukemogenesis.
References
Douglas, J., et al. Nat. Genet. 39(8):963-965(2007)
Xu, G., et al. Genomics 13(3):537-542(1992)
Wallace, M.R., et al. Nature 353(6347):864-866(1991)
Cawthon, R.M., et al. Genomics 9(3):446-460(1991)
Viskochil, D., et al. Mol. Cell. Biol. 11(2):906-912(1991)
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