EVI2B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P34910 |
Other Accession | NP_006486.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 48666 Da |
Antigen Region | 283-313 aa |
Gene ID | 2124 |
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Other Names | Protein EVI2B, Ecotropic viral integration site 2B protein homolog, EVI-2B, CD361, EVI2B, EVDB |
Target/Specificity | This EVI2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-313 amino acids from the Central region of human EVI2B. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | EVI2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EVI2B {ECO:0000303|PubMed:1903357, ECO:0000312|HGNC:HGNC:3500} |
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Function | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. |
Cellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Location | Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines. Strongly expressed in granulocytic cells, and weakly on lymphocytes cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
EVI2B (Ecotropic viral integration site 2B) may function as an oncogene in retrovirus-induced myeloid tumors and may have a role in leukemogenesis.
References
Douglas, J., et al. Nat. Genet. 39(8):963-965(2007)
Xu, G., et al. Genomics 13(3):537-542(1992)
Wallace, M.R., et al. Nature 353(6347):864-866(1991)
Cawthon, R.M., et al. Genomics 9(3):446-460(1991)
Viskochil, D., et al. Mol. Cell. Biol. 11(2):906-912(1991)
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