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MYBL1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P10243 |
| Other Accession | NP_001073885.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 85887 Da |
| Antigen Region | 510-536 aa |
| Gene ID | 4603 |
|---|---|
| Other Names | Myb-related protein A, A-Myb, Myb-like protein 1, MYBL1, AMYB |
| Target/Specificity | This MYBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 510-536 amino acids from the Central region of human MYBL1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MYBL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYBL1 |
|---|---|
| Synonyms | AMYB |
| Function | Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:7987850, PubMed:8058310). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P51960}. |
| Tissue Location | Expressed in a variety of lymphoid and solid tumor lines cultured in vitro |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.
References
Takahashi, T., et al. FEBS Lett. 358(1):89-96(1995)
Ma, X.P., et al. Cancer Res. 54(24):6512-6516(1994)
Golay, J., et al. Oncogene 9(9):2469-2479(1994)
Barletta, C., et al. Cancer Res. 51(14):3821-3824(1991)
Nomura, N., et al. Nucleic Acids Res. 16(23):11075-11089(1988)
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