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SHOC2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UQ13 |
| Other Accession | O88520, A6QLV3, NP_031399.2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64888 Da |
| Antigen Region | 56-83 aa |
| Gene ID | 8036 |
|---|---|
| Other Names | Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SHOC2, KIAA0862 |
| Target/Specificity | This SHOC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the N-terminal region of human SHOC2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SHOC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SHOC2 |
|---|---|
| Synonyms | KIAA0862 |
| Function | Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (PubMed:10783161, PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Acts as a scaffolding protein in the SMP complex (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:10783161, PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.
References
Matsunaga-Udagawa, R., et al. J. Biol. Chem. 285(10):7818-7826(2010)
Yoshiki, S., et al. Mol. Biol. Cell 21(6):1088-1096(2010)
Flotho, C., et al. Blood 115 (4), 913 (2010) :
Cordeddu, V., et al. Nat. Genet. 41(9):1022-1026(2009)
Rodriguez-Viciana, P., et al. Mol. Cell 22(2):217-230(2006)
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