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CCDC66 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | A2RUB6 |
| Other Accession | NP_001135419.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 109411 Da |
| Antigen Region | 690-719 aa |
| Gene ID | 285331 |
|---|---|
| Other Names | Coiled-coil domain-containing protein 66, CCDC66 |
| Target/Specificity | This CCDC66 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 690-719 amino acids from the C-terminal region of human CCDC66. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCDC66 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCDC66 (HGNC:27709) |
|---|---|
| Function | Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840). Required for the assembly of signaling-competent cilia with proper structure and length (PubMed:36606424). Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex (PubMed:36606424). Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation (PubMed:36606424). Plays two important roles during cell division (PubMed:35849559). First, is required for mitotic progression via regulation of spindle assembly, organization and orientation, levels of spindle microtubules (MTs), kinetochore-fiber integrity, and chromosome alignment (PubMed:35849559). Second, functions during cytokinesis in part by regulating assembly and organization of central spindle and midbody MTs (PubMed:35849559). Plays a role in retina morphogenesis and/or homeostasis (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (PubMed:28235840). Enriched in the inner segment of the photoreceptor (PubMed:19777273) |
| Tissue Location | Widely expressed (at protein level) (PubMed:28235840). Expressed in retina, mainly in photoreceptors but also in outer plexiform and ganglion cell layers (at protein level) (PubMed:19777273). |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein is unknown.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Kiel, D.P., et al. BMC Med. Genet. 8 SUPPL 1, S14 (2007) :
Toulza, E., et al. Genome Biol. 8 (6), R107 (2007) :
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$ 150.00
$ 385.00
Cat# AP17683b
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