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PTRH1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86Y79 |
| Other Accession | NP_001002913.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22937 Da |
| Antigen Region | 102-129 aa |
| Gene ID | 138428 |
|---|---|
| Other Names | Probable peptidyl-tRNA hydrolase, PTH, PTRH1, C9orf115 |
| Target/Specificity | This PTRH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-129 amino acids from the Central region of human PTRH1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTRH1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTRH1 {ECO:0000303|PubMed:30244831, ECO:0000312|HGNC:HGNC:27039} |
|---|---|
| Function | Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes (PubMed:30244831). Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes (PubMed:30244831). Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation (PubMed:30244831). |
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Provided below are standard protocols that you may find useful for product applications.
Background
C9orf115 belongs to the Peptidyl-tRNA hydrolase (PTH) family. Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through abortion of translation and is essential for cell viability.
References
Satoh, J., et al. Neuropathol. Appl. Neurobiol. 35(1):16-35(2009)
De Pereda, J.M., et al. J. Biol. Chem. 279(9):8111-8115(2004)
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