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CELA1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UNI1 |
| Other Accession | NP_001962.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27798 Da |
| Antigen Region | 51-79 aa |
| Gene ID | 1990 |
|---|---|
| Other Names | Chymotrypsin-like elastase family member 1, Elastase-1, Pancreatic elastase 1, CELA1, ELA1 |
| Target/Specificity | This CELA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human CELA1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CELA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CELA1 |
|---|---|
| Synonyms | ELA1 |
| Function | Serine proteases that hydrolyze many proteins in addition to elastin. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P00772}. |
| Tissue Location | Basal layers of epidermis (at protein level). Not expressed in the pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Talas, U., et al. J. Invest. Dermatol. 114(1):165-170(2000)
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