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ALX1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ALX1 Antibody (Center) AP17822c
    ALX1 Antibody (Center) (Cat. #AP17822c) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the ALX1 antibody detected the ALX1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q15699
Other Accession NP_008913.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 36961 Da
Antigen Region 97-122 aa
Additional Information
Gene ID 8092
Other Names ALX homeobox protein 1, Cartilage homeoprotein 1, CART-1, ALX1, CART1
Target/Specificity This ALX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-122 amino acids from the Central region of human ALX1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALX1 (HGNC:1494)
Function Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509).
Cellular Location Nucleus
Tissue Location Cartilage and cervix tissue.
Research Areas
Citations (0)
citation

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Background

The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq].

References

Uz, E., et al. Am. J. Hum. Genet. 86(5):789-796(2010)
Iioka, T., et al. J. Bone Miner. Res. 18(8):1419-1429(2003)
Qu, S., et al. Development 126(2):359-369(1999)
Cai, R.L. Biochem. Biophys. Res. Commun. 250(2):305-311(1998)
Gordon, D.F., et al. DNA Cell Biol. 15(7):531-541(1996)

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$ 182.50
$ 70.00
Cat# AP17822c
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