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INCA1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q0VD86 |
| Other Accession | NP_001161457.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26817 Da |
| Antigen Region | 14-42 aa |
| Gene ID | 388324 |
|---|---|
| Other Names | Protein INCA1, Inhibitor of CDK interacting with cyclin A1, INCA1 |
| Target/Specificity | This INCA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human INCA1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | INCA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INCA1 |
|---|---|
| Function | Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors (PubMed:15159402). Down- regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells (PubMed:21540187) |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Belongs to the INCA family.
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$ 385.00
$ 150.00
Cat# AP17905a
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