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MTL5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y4I5 |
| Other Accession | NP_001034745.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55025 Da |
| Antigen Region | 341-368 aa |
| Gene ID | 9633 |
|---|---|
| Other Names | Tesmin, Metallothionein-like 5, testis-specific, Testis-specific metallothionein-like protein, MTL5 |
| Target/Specificity | This MTL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 amino acids from the C-terminal region of human MTL5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTL5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TESMIN (HGNC:7446) |
|---|---|
| Synonyms | MTL5 |
| Function | Essential for normal spermatogenesis and male fertility (By similarity). Required for the completion of meiosis in male germ cells (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9WTJ6}. Nucleus {ECO:0000250|UniProtKB:Q9WTJ6}. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc {ECO:0000250|UniProtKB:Q9WTJ6} |
| Tissue Location | Expressed specifically in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene.
References
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Olesen, C., et al. Mol. Reprod. Dev. 67(1):116-126(2004)
Sutou, S., et al. Biol. Reprod. 68(5):1861-1869(2003)
Matsuura, T., et al. J. Inorg. Biochem. 88(2):183-191(2002)
Sugihara, T., et al. Genomics 57(1):130-136(1999)
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