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AFF2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P51816 |
| Other Accession | NP_001162593.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 144771 Da |
| Antigen Region | 886-912 aa |
| Gene ID | 2334 |
|---|---|
| Other Names | AF4/FMR2 family member 2, Fragile X E mental retardation syndrome protein, Fragile X mental retardation 2 protein, FMR2P, Protein FMR-2, Protein Ox19, AFF2, FMR2, OX19 |
| Target/Specificity | This AFF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 886-912 amino acids from the Central region of human AFF2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AFF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AFF2 (HGNC:3776) |
|---|---|
| Synonyms | FMR2, OX19 |
| Function | RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. |
| Cellular Location | Nucleus speckle. Note=When splicing is inhibited, accumulates in enlarged speckles |
| Tissue Location | Brain (most abundant in hippocampus and amygdala), placenta and lung |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a putative transcriptional activator that is a member of the AF4FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. Alternate splicing results in multiple transcript variants.
References
Bensaid, M., et al. Nucleic Acids Res. 37(4):1269-1279(2009)
Brylawski, B.P., et al. Exp. Mol. Pathol. 82(2):190-196(2007)
Sharma, D., et al. Genet. Epidemiol. 20(1):129-144(2001)
Hillman, M.A., et al. J. Hum. Genet. 46(5):251-259(2001)
Musumeci, S.A., et al. Clin Neurophysiol 111(9):1632-1636(2000)
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