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TTYH1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H313 |
| Other Accession | P0C5X8, Q9D3A9, Q9MZZ8, Q2KJ98, NP_001005367.1 |
| Reactivity | Human |
| Predicted | Bovine, Monkey, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49051 Da |
| Antigen Region | 2-28 aa |
| Gene ID | 57348 |
|---|---|
| Other Names | Protein tweety homolog 1, hTTY1, TTYH1 |
| Target/Specificity | This TTYH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-28 amino acids from the N-terminal region of human TTYH1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TTYH1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TTYH1 |
|---|---|
| Function | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in brain, eye, ovary and testis, and at lower levels in muscle, placenta, liver and lung |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Two transcript variants encoding distinct isoforms have been identified for this gene.
References
He, Y., et al. J. Biol. Chem. 283(35):24000-24010(2008)
Suzuki, M., et al. J. Biol. Chem. 279(21):22461-22468(2004)
Campbell, H.D., et al. Genomics 68(1):89-92(2000)
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