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B4GALNT1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q00973 |
| Other Accession | NP_001469.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58882 Da |
| Antigen Region | 296-323 aa |
| Gene ID | 2583 |
|---|---|
| Other Names | Beta-1, 4 N-acetylgalactosaminyltransferase 1, (N-acetylneuraminyl)-galactosylglucosylceramide, GM2/GD2 synthase, GalNAc-T, B4GALNT1, GALGT, SIAT2 |
| Target/Specificity | This B4GALNT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the Central region of human B4GALNT1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | B4GALNT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | B4GALNT1 (HGNC:4117) |
|---|---|
| Synonyms | GALGT, SIAT2 |
| Function | Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively. |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q10468}; Single-pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively.
References
Chen, L.C., et al. Lung Cancer 67(2):216-220(2010)
Boraska, V., et al. Clin. Biochem. 42(9):819-822(2009)
Gornati, R., et al. Mol. Cell. Biochem. 298 (1-2), 59-68 (2007) :
Li, J., et al. J. Biol. Chem. 275(52):41476-41486(2000)
Li, J., et al. J. Biol. Chem. 275(52):41476-41486(2000)
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