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B4GALNT1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant B4GALNT1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q00973 |
| Other Accession | NM_001478 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5F9 |
| Calculated MW | 58882 Da |
| Gene ID | 2583 |
|---|---|
| Other Names | Beta-1, 4 N-acetylgalactosaminyltransferase 1, (N-acetylneuraminyl)-galactosylglucosylceramide, GM2/GD2 synthase, GalNAc-T, B4GALNT1, GALGT, SIAT2 |
| Target/Specificity | B4GALNT1 (NP_001469, 30 a.a. ~ 127 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | B4GALNT1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively.
References
Analysis of GD2/GM2 synthase mRNA as a biomarker for small cell lung cancer. Chen LC, et al. Lung Cancer, 2010 Feb. PMID 19457569.Glycosyltransferase B4GALNT1 and type 1 diabetes in Croatian population: clinical investigation. Boraska V, et al. Clin Biochem, 2009 Jun. PMID 19318031.Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR. Gornati R, et al. Mol Cell Biochem, 2007 Apr. PMID 17119850.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.Disulfide bonds of GM2 synthase homodimers. Antiparallel orientation of the catalytic domains. Li J, et al. J Biol Chem, 2000 Dec 29. PMID 11018043.
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