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OSBPL11 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BXB4 |
| Other Accession | Q8CI95, NP_073613.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 83643 Da |
| Antigen Region | 76-102 aa |
| Gene ID | 114885 |
|---|---|
| Other Names | Oxysterol-binding protein-related protein 11, ORP-11, OSBP-related protein 11, OSBPL11, ORP11, OSBP12 |
| Target/Specificity | This OSBPL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-102 amino acids from the N-terminal region of human OSBPL11. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OSBPL11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OSBPL11 |
|---|---|
| Synonyms | ORP11, OSBP12 |
| Function | Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25- hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3- phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl- sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). |
| Cellular Location | Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi- late endosome interface |
| Tissue Location | Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level) (PubMed:23028956). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain.
References
Zhou, Y., et al. Exp. Cell Res. 316(19):3304-3316(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Bouchard, L., et al. Obesity (Silver Spring) 17(7):1466-1472(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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