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HIRIP3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BW71 |
| Other Accession | NP_003600.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61957 Da |
| Antigen Region | 287-316 aa |
| Gene ID | 8479 |
|---|---|
| Other Names | HIRA-interacting protein 3, HIRIP3 |
| Target/Specificity | This HIRIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-316 amino acids from the Central region of human HIRIP3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HIRIP3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HIRIP3 |
|---|---|
| Function | May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. |
| Cellular Location | Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis |
| Tissue Location | Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart |
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Provided below are standard protocols that you may find useful for product applications.
Background
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Recently, several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the HIRIP3 gene product binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism.
References
Kumar, R.A., et al. PLoS ONE 4 (2), E4582 (2009) :
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Assrir, N., et al. Biol. Chem. 388(4):391-398(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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