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MTHFS Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P49914 |
| Other Accession | NP_006432.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 23256 Da |
| Antigen Region | 133-159 aa |
| Gene ID | 10588 |
|---|---|
| Other Names | 5-formyltetrahydrofolate cyclo-ligase, 10-methenyl-tetrahydrofolate synthetase, MTHFS, Methenyl-THF synthetase, MTHFS |
| Target/Specificity | This MTHFS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the C-terminal region of human MTHFS. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTHFS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTHFS |
|---|---|
| Function | Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5- formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. |
| Cellular Location | Cytoplasm. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MTHFS contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
References
Kelemen, L.E., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1822-1830(2010)
Hazra, A., et al. Cancer Causes Control 21(3):331-345(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Wu, D., et al. Cancer Res. 69(18):7294-7301(2009)
Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)
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