STOML1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9UBI4 |
Other Accession | Q8CI66, NP_004800.2 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42968 Da |
Antigen Region | 1-30 aa |
Gene ID | 9399 |
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Other Names | Stomatin-like protein 1, SLP-1, EPB72-like protein 1, Protein unc-24 homolog, Stomatin-related protein, STORP, STOML1, SLP1, UNC24 |
Target/Specificity | This STOML1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human STOML1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | STOML1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | STOML1 |
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Synonyms | SLP1, UNC24 |
Function | May play a role in cholesterol transfer to late endosomes (PubMed:19696025). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202). |
Cellular Location | Membrane; Single-pass type III membrane protein. Late endosome membrane. Membrane raft. Cell membrane {ECO:0000250|UniProtKB:Q8CI66}; Single-pass type III membrane protein Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8CI66} |
Tissue Location | Ubiquitously expressed at low levels. Expression is highest in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
STOML1 belongs to the band 7/mec-2 family and contains one SCP2 domain. It is ubiquitously expressed at low levels; expression is highest in brain. There are two named isoforms.
References
Mairhofer, M., et al. J. Biol. Chem. 284(42):29218-29229(2009)
Gilles, F., et al. Eur. J. Haematol. 64(2):104-113(2000)
Seidel, G., et al. Gene 225 (1-2), 23-29 (1998) :
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