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TBC1D20 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96BZ9 |
| Other Accession | NP_653229.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45855 Da |
| Antigen Region | 335-363 aa |
| Gene ID | 128637 |
|---|---|
| Other Names | TBC1 domain family member 20, TBC1D20, C20orf140 |
| Target/Specificity | This TBC1D20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the C-terminal region of human TBC1D20. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TBC1D20 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TBC1D20 (HGNC:16133) |
|---|---|
| Synonyms | C20orf140 |
| Function | GTPase-activating protein (GAP) specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude (PubMed:23236136). Also shows GAP activity for RAB18 GTPase (PubMed:26063829). Promotes RAB18 dissociation from the endoplasmic reticulum (ER) membrane into the cytosol, probably through stimulating RAB18 GTP-hydrolysis (PubMed:26063829). Involved in maintaining endoplasmic reticulum structure (PubMed:24891604). |
| Cellular Location | Membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TBC1D20 may act as a GTPase-activating protein for Rab family protein(s).
References
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Sklan, E.H., et al. J. Biol. Chem. 282(50):36354-36361(2007)
Sklan, E.H., et al. J. Virol. 81(20):11096-11105(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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