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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > Mouse Pnpla3 Antibody (C-term)
Mouse Pnpla3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q91WW7 |
| Other Accession | NP_473429.2 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45772 Da |
| Antigen Region | 366-393 aa |
| Gene ID | 116939 |
|---|---|
| Other Names | Patatin-like phospholipase domain-containing protein 3, Acylglycerol O-acyltransferase, 231-, Adiponutrin, Calcium-independent phospholipase A2-epsilon, iPLA2-epsilon, Pnpla3, Adpn |
| Target/Specificity | This Mouse Pnpla3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-393 amino acids from the C-terminal region of mouse Pnpla3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Pnpla3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Pnpla3 {ECO:0000312|MGI:MGI:2151796} |
|---|---|
| Synonyms | Adpn |
| Function | Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (By similarity). In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (By similarity). However, the triacylglycerol hydrolase activity is controversial and may be very low (PubMed:22560221). Possesses phospholipase A2 activity (By similarity). |
| Cellular Location | Membrane; Single-pass membrane protein. Lipid droplet |
| Tissue Location | Restricted to adipose tissue. Expressed in inguinal and epididymal white adipose tissues and in interscapular brown adipose tissue (PubMed:11431482). Also expressed in liver in response to high- sucrose diet (PubMed:22560221). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities (By similarity).
References
Chen, W., et al. Hepatology 52(3):1134-1142(2010)
Hoekstra, M., et al. J. Hepatol. 52(2):244-251(2010)
Kershaw, E.E., et al. Diabetes 55(1):148-157(2006)
Baulande, S., et al. J. Biol. Chem. 276(36):33336-33344(2001)
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$ 150.00
$ 385.00
Cat# AP18690b
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