GMCL1L Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8NEA9 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 60299 Da |
Antigen Region | 498-524 aa |
Other Names | Putative germ cell-less protein-like 1-like, GMCL1P1, GCL, GMCL1L |
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Target/Specificity | This GMCL1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-524 amino acids from the C-terminal region of human GMCL1L. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GMCL1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GMCL2 (HGNC:19717) |
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Synonyms | GCL, GMCL1L, GMCL1P1 |
Function | Possible function in spermatogenesis. Probable substrate- specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). |
Cellular Location | Nucleus matrix {ECO:0000250|UniProtKB:Q920G9}. |
Tissue Location | Expressed predominantly in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GMCL1L is possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
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