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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > MBD6 Antibody (C-term)
MBD6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96DN6 |
| Other Accession | Q3TY92, NP_443129.3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101201 Da |
| Antigen Region | 977-1003 aa |
| Gene ID | 114785 |
|---|---|
| Other Names | Methyl-CpG-binding domain protein 6, Methyl-CpG-binding protein MBD6, MBD6, KIAA1887 |
| Target/Specificity | This MBD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 977-1003 amino acids from the C-terminal region of human MBD6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MBD6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MBD6 |
|---|---|
| Synonyms | KIAA1887 |
| Function | Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:24634419). Important for stability of PR-DUB components and stimulating its ubiquitinase activity (PubMed:36180891). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways (PubMed:36180891). Heterochromatin recruitment is not mediated by DNA methylation (PubMed:20700456). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability; may promote cancer cell growth (PubMed:36180891). |
| Cellular Location | Nucleus. Chromosome. Note=Associates with heterochromatin containing chromocentres in a subset of cells in a DNA methylation- independent manner (PubMed:20700456). Localizes to sites of DNA damage independent of the PR-DUB complex (PubMed:24634419) |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
References
Laget, S., et al. PLoS ONE 5 (8), E11982 (2010) :
Roloff, T.C., et al. BMC Genomics 4 (1), 1 (2003) :
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$ 150.00
$ 385.00
Cat# AP18913B
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